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IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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What is Vagifem?

True Canada Pharmacy is a safe, affordable online pharmacy which makes ordering Canadian drugs such as Vagifem hassle-free. We can help you to save up to 90% on the cost of your medications. Buy your medications online from our Canadian pharmacy today!

Vagifem (estradiol) is a female hormone medication that is prescribed to treat vaginal menopause symptoms which may include painful sexual intercourse, vaginal dryness, vaginal itching or burning. These symptoms are caused by your body producing less of the female hormone estrogen which regulates many body processes.

Always read the medication information and instructions before using this medication.
Always follow your doctor’s directions.

  • Vagifem is estradiol tablets and is preloaded into individual applicators.
  • Follow your doctor’s directions for how and when to take Vagifem. It is typically taken daily for the initial two weeks of treatment and then taken twice a week.
  • Insert the Vagifem applicator into your vagina gently. Press down on the plunger to release the medication.
  • If a tablet falls out of the applicator before it is inserted, discard it and use a new applicator.
  • Vagifem should be used regularly to be most effective.
  • Speak to your doctor if your condition does not improve.


Make sure to tell your doctor:

  • If you have any drug or other allergies.
  • If you take any other prescription or over-the-counter medications.
  • Your medical history especially of uterus problems, vaginal bleeding, heart disease, heart attack, kidney disease, liver disease, cancer, seizures, migraines, asthma, high blood pressure, diabetes, blood clotting disorders, stroke, obesity, lupus, an underactive thyroid, obesity, porphyria, mental or mood disorders, mineral imbalance, hypoparathyroidism, gallbladder disease or high cholesterol levels.
  • Your family and personal history of blood clots, cancer, angioedema or breast lumps.
  • If you have recently had surgery or will be having surgery as this may increase the chance of blood clots. You may need to temporarily stop taking Vagifem.
  • If you are breast-feeding.

Other information you should also know:

  • Smoking and using tobacco while using Vagifem further increases your risk of heart attack, stroke, blood clots and high blood pressure. This is even more likely if you are over 35. Do not smoke or use tobacco products while you are using Vagifem.
  • Vagifem should not be used during pregnancy.
  • You should have regular breast exams and gynecology check-ups while taking Vagifem.
  • Older adults may be more sensitive to the side effects of Vagifem.

Side Effects

Common side effects of Vagifem:

  • Breast tenderness.
  • Weight changes.
  • Bloating.
  • Headaches.
  • Diarrhea.
  • Nausea or vomiting.

If you have any of the following estradiol side effects, seek medical help:

  • New or increased vaginal itching, discharge, odor bleeding or irritation.
  • Unusual vaginal bleeding including spotting, breakthrough bleeding, prolonged or recurrent bleeding.
  • Persistent vomiting or nausea.
  • Mental or mood changes including memory loss or depression.
  • Breast lumps.
  • Severe stomach or abdominal pain.
  • Increased thirst or urination.
  • Swelling of the hands or feet.
  • Dark urine.
  • Jaundice.
  • Serious problems from blood clot such as vision changes, confusion, sudden dizziness, fainting, unusual sweating, slurred speech, sudden or severe headache, coughing up blood, weakness or numbness in your arms or legs, breathing problems, pain in your chest, jaw or left arm, weakness on one side of the body, tingling or pain, redness or swelling of the legs.
  • Symptoms of an allergic reaction including difficulty breathing, hives or swelling in your face, lips or throat.


What should I do if my Vagifem tablet comes out of the applicator?

Discard the tablet and use a new applicator.

What is the strength of Vagifem?

Vagifem is available in a 10mcg strength.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-204-1509 and a member of our CareTeam will be happy to assist you.

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* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

Real Customers, Honest Reviews

The last order came in a timely fashion and like all others, service has been without any problems. Keep up the excellent work.
Harold August 30, 2021

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The medication to treated SIBO in the USA is absolutely over priced as it has to be used usually twice a year. True Canada Pharmacy helped me obtain 2+ treatment doses of it for far, far, far less than 1 treatment dose cost in the USA. Due to the pandemic it takes a while to get it but we are all set for the next time it recurs. Thank you so very much.
Cryss August 30, 2021

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Very easy to refill. Quick delivery
Pam August 30, 2021

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I was frustrated with the Visa payment system being inoperable, but I have to say that when they went ahead a filled the Rx and said they would process the claim when it went back up, that was exceptional service - thank you
Christopher July 27, 2021

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Your representative are very thorough, knowledgeable, and helpful.
Randy July 27, 2021

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Always friendly and helpful. Product arrived in a timely manner. Was kept up to date on the process on the mailing process
Rita July 27, 2021

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I very much appreciate the reminders and efficiency of the staff.
Monica July 26, 2021

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We have been very happy with the service.
Mary July 26, 2021

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I have used Canadian Pharmacy for at least 10-12 years. I have been very grateful to be able to get my life saving scripts at reasonable affordable prices. The follow-up of your Reps is excellent. During the COVID 19 virus outbreak scripts took much longer to receive. I think thus was partly due to the U.S.P.S. assault by DeJoy as Postmaster General. Before COVID 19 it took approx. 2-3 weeks to receive meds; during COVID 19 and the US General Election year, it took easily 2 months to receive scripts. It will be interesting to see if future orders arrive any more quickly after DeJoy is no longer Postmaster General?!
Jennifer June 9, 2021

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Good experience. I found another pharmacy with a lower price than yours, and you did lower the price for me. It took some time to get everything straight, so you expedited the mail and I received it on time. Thank you.
Linda May 25, 2021
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