Trelegy Ellipta combines fluticasone furoate, umeclidinium bromide, and vilanterol trifenatate to treat symptoms of asthma and chronic obstructive pulmonary disease (COPD). When used properly, this medication can alleviate symptoms such as chronic cough, shortness of breath, fatigue, and wheezing. Fluticasone is a steroid, vilanterol is a bronchodilator, and umeclidinium is an anticholinergic. Together, they can help with better breathing and prevent bronchospasms. Trelegy Ellipta is not a quick-relief inhaler. Use only fast-acting inhalation medicine during an asthma attack.

Use Trelegy Ellipta exactly as directed by your doctor. More information can be found on the package label included by the manufacturer.

• Do not use Trelegy Ellipta as a rescue medicine. Trelegy Ellipta does not work quickly enough to relieve asthma attacks.
• Do not change your dose or dosing schedule without consulting your doctor
• Attend frequent medical checks, especially for vision and bone mineral density
• After using, rinse with water but do not swallow. Rinsing helps prevent yeast infections in the mouth
• Store this medication at room temperature and out of the reach of children
• Ask your doctor for a refill once the inhaler counter falls below 10. Dispose the inhaler device 6 weeks after removal from the foil pouch or when the indicator shows zero, whichever comes first

Certain health conditions may make Trelegy Ellipta unsuitable for you. To avoid complications, inform your doctor if you have:

• High blood pressure
• A history of seizures or epilepsy
• Osteoporosis (a disease that weakens and thins the bones)
• Glaucoma
• Cataracts
• Heart attack or stroke
• Diabetes
• Thyroid issues (hyperthyroidism or hypothyroidism)

Certain medications may interact with Trelegy Ellipta and cause adverse effects. Before taking Trelegy Ellipta, let your doctor know if you are taking:

• Atropine (used to treat symptoms of bradycardia or low heart rate)
• Antifungal or antiviral medicine
• Mental disorder medication
• Cold suppressants like amantadine and rimantadine
• Drugs to treat Parkinson’s disease, including istradefylline and levodopa/carbidopa
• Irritable bowel syndrome (IBS) drugs
• Overactive bladder (OAB) treatments
• Bronchodilators like formoterol and tiotropium

Trelegy Ellipta may cause certain side effects, such as:

• Nausea or vomiting
• Mild to moderate headache
• Joint pain, back pain, or mouth pain
• Runny nose
• Sore throat
• Other cold symptoms, including acute or persistent coughing

More severe side effects should be reported to your doctor as soon as possible. Severe side effects of Trelegy Ellipta may include:

• Difficulty breathing or shortness of breath
• Wheezing or chest tightness
• Mouth sores, including lesions that appear on the lips gums and tongue
• Painful or difficult urination
• Low potassium levels (muscle damage or pain, tiredness, and heart palpitations)
• Involuntary shaking of one or more body parts (tremors)
• High blood sugar
• Blurred vision

Are there substances I should avoid while taking Trelegy Ellipta?

An interaction between two or more medications can lead to adverse symptoms and an increased risk of side effects. Common drugs that interact with Trelegy Ellipta include metformin, albuterol, furosemide, prednisone, and trazadone. This list of Trelegy Ellipta interactions is not complete. Ask your doctor before taking a new medication, herbal medicine, or supplement to ensure there are no interactions. Additionally, avoid sick people when taking Trelegy Ellipta because this drug may increase your risk of severe chickenpox or measles if infected.

Can I use Trelegy Ellipta while pregnant?

Use of Trelegy Ellipta is only recommended during pregnancy if the benefit clearly outweighs the risks. There is currently not enough data to conclude whether Trelegy Ellipta is safe for pregnant women. However, asthma during labor can increase the risk of complications, so your doctor may prescribe this inhalation medication if necessary.