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Combigan (brimonidine/timolol) is an eye drop medication used to treat open-angle glaucoma, ocular hypertension and other forms of high pressure inside the eye. The two medications brimonidine and timolol work together to treat these conditions. Brimonidine reduces the amount of fluid inside your eye by allowing better drainage while timolol reduces the pressure inside your eye.

Always read the medication information and instructions before using this medication.
Always follow your doctor’s directions.

• Combigan is typically used twice a day, twelve hours apart.
• Wash your hands before applying Combigan.
• Tilt your head backwards. Pull your lower eyelid down with your finger in order to create a pocket. Look upwards and away from the dropper and squeeze out a drop into the eye socket.
• Hold your finger to the inside corner of your eye to stop liquid draining out.
• If your doctor has directed you to take multiple drops, wait five minutes between drops. If you use any other eye drop medications, wait at least ten minutes before applying these.
• Do not use Combigan if the liquid has particles in it or has changed colour.
• Do not touch the dropper or let it touch any surface to avoid contamination.

Make sure to tell your doctor:

• If you have any drug or other allergies.
• If you take any other prescription or over-the-counter medications.
• Your medical history especially of glaucoma, lung disease, congestive or severe heart failure, heart disease, AV block, coronary artery disease, kidney disease, liver disease, stroke, blood clot, circulation problems, asthma, high or low blood pressure, depression, thyroid disorder, diabetes or myasthenia gravis.
• If you are pregnant or planning pregnancy.
• If you are breast-feeding.
• If you develop an eye infection or eye injury or if you have eye surgery while using Combigan. You may need to start using a new bottle of medication.

Other information you should also know:

• If you are diabetic, Combigan may prevent the fast or pounding heartbeat that you associate with low blood sugar.
• Combigan may blur your vision or make you drowsy or dizzy. Do not drive or do any other activity which requires clear vision or alertness until you can do it safely.

Common side effects of Combigan:

• Temporary blurred vision.
• Temporary eye burning, itching or stinging.
• Watery or dry eyes.
• Feeling like there is something in your eye.
• Dry mouth.
• Headaches.
• Dizziness.
• Drowsiness.

If you have any of the following Combigan side effects, seek medical help:

• Vision changes.
• Sensitivity to light.
• Eye swelling, pain or discharge.
• Mental or mood changes.
• Muscle weakness or unusual tiredness.
• Slow or irregular heartbeat.
• Numbness, pain or coldness in the hands or feet.
• Shortness of breath.
• Sudden or unexplained weight gain.
• Swelling of your feet or ankles.
• Symptoms of an allergic reaction including difficulty breathing, hives or swelling in your face, lips or throat.

What should I do if I miss a dose of Combigan?

If you miss a dose of Combigan, you should take it as soon as you remember. However, if it is almost time for your next dose, then skip your missed dose.

What should I do if my Combigan medication has particles in it?

Do not use Combigan if it has particles in it or if it has changed colour. Use a new bottle of medication.